This study describes access to individual patient-level data from randomized clinical trials during the COVID-19 pandemic to determine whether the intent to share what was reported in the registry, publication, or preprint was consistent with actual data access.
Source: JAMA Online First

In this narrative medicine essay, a pediatric critical care physician imagines the future discussion with her son about his conception and birth and recounts how she and her husband decided on expanding their family via gestational surrogacy.
Source: JAMA Online First

This Viewpoint looks back at the US Supreme Court’s 2021 and 2022 terms and forward to the 2023 term and beyond with a focus on decisions that affect health care, public health and safety, environmental policy, and social equity.
Source: JAMA Online First

This study examines the dissemination of trial results by data source (ie, ClinicalTrials.gov and PubMed) and funder type (ie, industry and nonindustry).
Source: JAMA Online First

This Viewpoint recommends increasing US global health funding levels, outlines steps for ensuring optimal integration and coordination of activities, and discusses ways to elevate noncommunicable diseases.
Source: JAMA Online First

Revumenib, an investigational drug that inhibits a protein called menin, had minimal severe adverse effects when administered orally twice a day, according to results from a phase 1 clinical trial involving 68 participants with relapsed or refractory acute leukemia. The trial specifically tested the agent among patients whose leukemias were characterized by rearrangement of the KMT2A gene or variation of the NPM1 gene; these types of leukemias depend on menin.
Source: JAMA Online First

Memory CD4 T cells generated after infection with OC43, a common cold coronavirus, also exhibited an immune response against SARS-CoV-2 in early childhood, according to results from 2- and 6-year-old children and adults who did not have antibodies against the novel coronavirus and from a group of adults who had recovered from COVID-19. By age 2 years, many children had antibodies against OC43; by age 6, the reactivity of the CD4 T cells had peaked and then declined in adulthood.
Source: JAMA Online First

This Medical News article discusses recent announcements of price caps on some insulins.
Source: JAMA Online First

This study uses 2021 National Health Interview Survey data to examine the prevalence of insulin rationing among adults younger than 65 years in the US by demographic characteristics.
Source: JAMA Online First

This Viewpoint investigates whether political pressure such as that used to decrease insulin pricing is a feasible method of lowering the cost of other drugs.
Source: JAMA Online First