LAURA H. CYPHERS

This study examines the frequency of drug patent invalidations based on inequitable conduct.
Source: JAMA Online First

This randomized clinical trial compares a single dose of lepodisiran vs placebo to assess the safety, tolerability, pharmacokinetics, and effects on lipoprotein(a) concentrations in adults without cardiovascular disease and with lipoprotein(a) serum concentrations of 75 nmol/L or greater at baseline.
Source: JAMA Online First

Artificial intelligence (AI) is already revolutionizing the conduct of science and the practice of medicine. From basic discovery to gaining insights about someone’s health through machine-eyes, new applications of AI are announced almost daily. AI is increasingly being used to enhance the practice of medicine with action ranging from augmenting human judgment to full task automation. The potential for AI to transform clinical research is also great, and the progress already observed in discovery science and applications to medicine are critically needed in the clinical research domain. This Editorial highlights the findings of a new article in JAMA Cardiology that examines the potential for natural language processing (NLP) models to accurately classify heart failure hospitalizations compared with the gold standard for clinical adjudication and places the findings from this study in context of the possibilities for improving clinical trials through AI.
Source: JAMA Online First

This cross-sectional, exploratory study uses ClinicalTrials.gov data from trials initiated on or after January 18, 2017, to characterize the use of a new free-text “gender eligibility description” data field; reports the frequency of gender identity terms used; and assesses the correct or incorrect use of the field.
Source: JAMA Online First

This study quantifies the change in travel times for military service personnel to abortion facilities following the US Supreme Court Dobbs decision and estimates the cost of an abortion-related travel reimbursement policy.
Source: JAMA Online First

This JAMA Patient Page describes the types and symptoms of pituitary adenomas and their diagnosis and treatment.
Source: JAMA Online First

In this narrative medicine essay, a pediatric oncologist grapples with the emotions of loss and guilt while attending the memorial service of her 8-year-old patient.
Source: JAMA Online First

Promoting the science and art of medicine for the betterment of human health is central to JAMA’s mission and is fulfilled in part by publishing articles with up-to-date evidence on common health problems that are timely and practical for clinicians. Narrative reviews, an important component of JAMA’s Clinical Review and Education section, provide evidence-based and timely summaries of topics relevant for the practicing generalist clinician. Recent JAMA narrative reviews have covered prediabetes, hyperthyroidism, and care of adults who survived childhood cancer.
Source: JAMA Online First

This review summarizes evidence regarding Black race and inequities in outcomes of hepatitis C virus (HCV) infection because of the high prevalence and absolute number of annual HCV-related deaths in Black populations relative to other racial and ethnic minority groups.
Source: JAMA Online First

This review summarizes current evidence regarding diagnosis and treatment of hepatitis D virus.
Source: JAMA Online First