Approximately 10% of patients diagnosed with cancer have a germline variant in a gene that increases susceptibility to cancer. The most common examples include germline pathogenic variants (mutations) in BRCA1 and BRCA2, which are associated with an increased risk of breast, ovarian, pancreatic, and prostate cancer, and germline pathogenic variants in MLH1, MSH2, MSH6, and PMS2 (Lynch syndrome), which are associated with increased risk of colorectal cancer, endometrial cancer, and other cancer types.
Source: JAMA Online First
This observational study describes the prevalence of germline genetic testing in California and Georgia between 2013 and 2019 among patients diagnosed with cancer.
Source: JAMA Online First
This randomized trial assesses the comparative effectiveness of direct oral anticoagulants vs low-molecular-weight heparin on rate of 6-month recurrence of venous thromboembolism (VTE) among patients with cancer who had a new diagnosis of VTE.
Source: JAMA Online First
In this narrative medicine essay, a palliative care physician discusses how the simple choice of words and the act of listening can redirect a patient’s despair to hope in helping them rewrite their narratives.
Source: JAMA Online First
This Viewpoint discusses a recent federal court decision that invaliated the Food and Drug Administration’s (FDA) approval of mifepristone, a drug used to end pregnancies and manage miscarriage when used with misoprostol, and how that decision challenges the legitimacy and independence of the FDA.
Source: JAMA Online First
This Viewpoint examines an approach known as normothermic regional perfusion, involving use of ECMO to restore perfusion to internal organs in situ before they are removed from a deceased donor.
Source: JAMA Online First
This JAMA Insights Clinical Update discusses the management of ectopic pregnancy and the urgency of prompt intervention.
Source: JAMA Online First
This Viewpoint explains the use of opportunistic salpingectomy, removal of the fallopian tubes for the primary prevention of ovarian cancer in a woman already undergoing pelvic surgery for another indication.
Source: JAMA Online First
This Viewpoint discusses the proliferation of decentralized clinical trials during the COVID-19 pandemic and the need for rigorous studies to inform whether decentralized approaches promote or prevent access to clinical trials for people facing health disparities.
Source: JAMA Online First
A global collaboration, known as the International Pathogen Surveillance Network, will harness pathogen genomics to improve disease surveillance and identify and respond to disease-causing agents before they become pandemics or epidemics, the World Health Organization (WHO) announced. The Network will connect members of different countries to improve sample collection and analysis and facilitate public health decision-making, among other goals.
Source: JAMA Online First