LAURA H. CYPHERS

This study compares data on the symptoms of posttraumatic stress disorder (PTSD) among family members of patients with acute respiratory distress syndrome (ARDS) caused by COVID-19 vs non–COVID-19 ARDS.
Source: JAMA Online First

This Viewpoint explores a critical source of administrative burden and physician frustration—the explosive growth of health care quality metrics—and how improving these metrics could combat clinician burnout.
Source: JAMA Online First

An increasing number of clinicians and researchers have become interested in the potential of psychedelic drugs for the treatment of mental health disorders, including depression, anxiety, posttraumatic stress disorder, eating disorders, and addictions.
Source: JAMA Online First

This randomized clinical trial examines the timing of onset of action, durability of benefit, and safety profile of single-dose psilocybin in patients with major depressive disorder compared with placebo.
Source: JAMA Online First

People who had severe COVID-19 might experience long-lasting, detrimental changes in the innate immune system, a small study in Cell suggests. Researchers observed epigenetic changes in blood-forming stem cells in participants with COVID-19 who required intubation and mechanical ventilation compared with healthy participants and those who experienced other severe illnesses. The changes ultimately resulted in higher levels of inflammatory molecules known as cytokines, the study involving 57 participants found.
Source: JAMA Online First

Continuing a years-long upward trend, the proportion of US adults aged 35 to 50 years who reported binge drinking reached a “historic” high in 2022, with almost a third of people stating that they had consumed 5 or more drinks in a row in the past 2 weeks. Use of other substances, such as marijuana and hallucinogens, also increased among midlife adults compared with previous years, according to a National Institute on Drug Abuse report that included survey responses from 5450 people.
Source: JAMA Online First

Partial resistance to the antimalaria drug artemisinin has increased across Uganda in recent years, according to surveillance results from multiple sites across the country between 2016 and 2022. In the majority of sites surveyed, more than 20% of Plasmodium falciparum parasites exhibited signs of resistance, defined as slow clearance of the organism from a person’s body after treatment.
Source: JAMA Online First

This Medical News article discusses the successes and challenges of the 988 Suicide & Crisis Lifeline following its first anniversary.
Source: JAMA Online First

After deep brain stimulation (DBS) of the cerebellar dentate nucleus, a brain region involved in control of voluntary movements, 9 out of 12 patients who had experienced a stroke up to 3 years earlier experienced clinically important improvements in motor function and decreases in impairment, according to results from a phase 1 trial published in Nature Medicine.
Source: JAMA Online First

A patient who had recently undergone bilateral mastectomy had erythema, edema, pain, pruritus, serous fluid drainage at the incision sites, and an erythematous papulovesicular rash on the trunk and extremities. A skin swab bacterial culture result was negative, and the skin findings did not improve with antibiotics. What is the diagnosis and what would you do next?
Source: JAMA Online First