LAURA H. CYPHERS

Sepsis describes life-threatening organ dysfunction due to a dysregulated host response to infection. It is a global health priority affecting 55 million people worldwide causing 11 million deaths annually. Failure to initiate timely antibiotic therapy for sepsis can result in progression to septic shock, which is associated with a mortality rate of 30% to 40%. Accordingly, sepsis is recognized as a time-critical medical emergency.
Source: JAMA Online First

This randomized clinical trial compares the use of cefepime vs piperacillin-tazobactam and the risk of acute kidney injury and neurological dysfunction in adults hospitalized with acute infection.
Source: JAMA Online First

This Viewpoint discusses the importance of collaboration among the agencies responsible for documenting rates of maternal mortality to ensure more accurate, reliable, and timely estimates.
Source: JAMA Online First

This Viewpoint discusses the National Institutes of Health initiative that focuses on research that reduces preventable maternal mortality, decreases severe maternal morbidity, and promotes health equity.
Source: JAMA Online First

This cross-sectional study describes the prevalence of Acinetobacter baumannii and Candida auris among patients receiving mechanical ventilation in hospitals and long-term care facilities in Maryland.
Source: JAMA Online First

This clinical trial examines whether early, empirical, high-dose cryoprecipitate, in addition to standard major hemorrhage protocols, would improve survival in the first 28 days after hospital admission following injury.
Source: JAMA Online First

This Viewpoint discusses how patient blood management can help curb the demand for blood products and reduce harm by determining who would most benefit from a blood transfusion.
Source: JAMA Online First

Red blood cell transfusion threshold guidelines from the AABB transfusion medicine association have been updated to incorporate an expanded evidence base and to introduce guidance specific to children.
Source: JAMA Online First

This Viewpoint reviews the vicissitudes of establishing fair and equitable blood donation policies based on research and improved serological testing and promotes expanding the pool of potential donors.
Source: JAMA Online First

This Viewpoint investigates supply and policy barriers to ready availability of blood products and suggests solutions to improve patient outcomes.
Source: JAMA Online First