Men who received testosterone therapy for an average of about 22 months did not experience a greater number of major adverse cardiac events compared with those who received a placebo, based on results from a randomized clinical trial that enrolled 5246 patients aged 45 to 80 years. All participants had low levels of testosterone as well as symptoms of underfunctioning gonads—such as decreased libido, low mood, or loss of body hair—in addition to a preexisting or high risk of cardiovascular disease.
Source: JAMA Online First